Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | UBE2I | P63279 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708467 | 0.85 | KCNH2 (0.57) | KCNH2KDM1AUBE2IHKDC1SAE1 | |
| SCHEMBL921899 | 0.80 | KCNH2 (0.59) | KCNH2UBE2IHKDC1SAE1UBA2 | |
| SCHEMBL705556 | 0.80 | KCNH2 (0.52) | KCNH2UBE2IHKDC1SAE1UBA2 | |
| Trifluoroacetic Acid SCHEMBL705051 | 0.78 | KCNH2 (0.51) | KCNH2UBE2IHKDC1SAE1UBA2 | |
| Trifluoroacetic Acid SCHEMBL704661 | 0.74 | KCNH2 (0.43) | KCNH2CHRM1 | |
| SCHEMBL706058 | 0.73 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL706037 | 0.70 | KCNH2 (0.70) | KCNH2HTR2A | |
| SCHEMBL6602559 | 0.67 | LMNA (0.49) | OXTRKDM4EHSD17B10 | |
| SCHEMBL30293275 | 0.67 | LMNA (0.49) | OXTRKDM4EHSD17B10 | |
| SCHEMBL31033195 | 0.67 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |