Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27395269 | 0.98 | CES2 (0.44) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL27981154 | 0.74 | CES2 (0.39) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL1617657 | 0.74 | SMN1; SMN2 (0.40) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL1911562 | 0.72 | CES2 (0.46) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL21396924 | 0.71 | CES2 (0.37) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL21765808 | 0.71 | CES2 (0.41) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL182225 | 0.70 | MAPK1 (0.50) | ALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL16674533 | 0.70 | CES2 (0.50) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL11714520 | 0.70 | CES2 (0.50) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL1228934 | 0.70 | CES2 (0.50) | CES2CES1SMN1; SMN2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |