Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091676 | 0.80 | SMN1; SMN2 (0.39) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL3826078 | 0.80 | SMN1; SMN2 (0.39) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL6710646 | 0.79 | SMN1; SMN2 (0.33) | SMN1; SMN2TSHRALDH1A1THRB | |
| SCHEMBL1617657 | 0.78 | SMN1; SMN2 (0.40) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL942071 | 0.78 | ALDH1A1 (0.46) | SMN1; SMN2TSHRALDH1A1NPSR1SLC6A3 | |
| SCHEMBL17504886 | 0.75 | TSHR (0.40) | SMN1; SMN2TSHRPADI1PADI4TP53 | |
| SCHEMBL27395269 | 0.74 | CES2 (0.44) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL29102026 | 0.73 | CES2 (0.39) | CES2CES1SMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL2001451 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2TSHRALDH1A1NPSR1SLC6A3 | |
| SCHEMBL10901570 | 0.73 | SMN1; SMN2 (0.34) | CES2CES1SMN1; SMN2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613742-A1 | INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE | Kind Pharmaceutical (CN) | 2020-02-26 | — | — | EP | disclosed |