Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134292 | 0.84 | KIF11 (0.45) | KIF11MAPK8SCN9ASCN3AFFAR4 | |
| SCHEMBL5123239 | 0.71 | CASP3 (0.36) | KIF11MAPK8EPHX2CHEK1SCN9A | |
| SCHEMBL14033481 | 0.70 | EPHX2 (0.37) | KIF11MAPK8EPHX2CHEK1SCN9A | |
| SCHEMBL5052822 | 0.69 | CASP3 (0.41) | KIF11SCN9ASCN5ACASP3 | |
| SCHEMBL14605699 | 0.69 | KIF11 (0.41) | KIF11MAPK8EPHX2SCN9ASCN5A | |
| SCHEMBL5123243 | 0.66 | CASP3 (0.36) | KIF11MAPK8EPHX2ERCC5FEN1 | |
| SCHEMBL5971941 | 0.65 | KIF11 (0.50) | KIF11EPHX2MAPT | |
| SCHEMBL14875138 | 0.65 | FFAR4 (0.47) | KIF11EPHX2FFAR4MAPTPTGS2 | |
| SCHEMBL14572634 | 0.63 | SCN9A (0.47) | KIF11SCN9AFFAR4PTGS2PTGS1 | |
| SCHEMBL3176978 | 0.63 | FFAR4 (0.49) | KIF11EPHX2FFAR4MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940767-A2 | PPARACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030567-A2 | PPARACTIVE COMPOUNDS | PLEXXIKON, INC. (US) | 2007-03-15 | — | — | WO | disclosed |