Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | CCR3 | P51677 | 6/20 | 0.40 |
| ▸ | DDX3X | O00571 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | FPR3 | P25089 | 2/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201129 | 0.90 | RORC (0.48) | RORCFPR3CCR1GPR65GPR35 | |
| SCHEMBL3210124 | 0.86 | HTR1A (0.45) | HTR1AHTR1DHTR1BCCR3DDX3X | |
| SCHEMBL545635 | 0.83 | HTR1A (0.43) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL401663 | 0.81 | HTR1A (0.42) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL402430 | 0.81 | HTR1A (0.42) | HTR1AHTR1DHTR1BCCR3DDX3X | |
| SCHEMBL3208943 | 0.81 | HTR1A (0.50) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL402570 | 0.80 | HRH2 (0.46) | HTR1AHTR1DHTR1BDDX3X | |
| SCHEMBL402096 | 0.79 | CYP1A2 (0.46) | HTR1AHTR1DHTR1BCCR3DDX3X | |
| SCHEMBL401052 | 0.78 | HTR1A (0.40) | HTR1AHTR1DHTR1BDDX3XMAPK10 | |
| SCHEMBL5135180 | 0.78 | RORC (0.45) | RORCFPR3CCR1GPR65GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |