Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134154 | 0.76 | CCNA2 (0.48) | PTK2AURKA | |
| SCHEMBL4900033 | 0.75 | PDE5A (0.48) | PDE5A | |
| SCHEMBL5134597 | 0.75 | PIK3CB (0.34) | PIK3CB | |
| SCHEMBL5133695 | 0.72 | PDE10A (0.41) | PDE5ACLK4 | |
| SCHEMBL18876154 | 0.69 | PRKCI (0.52) | TRPV1CACNA1HCHRNA7PIK3CB | |
| SCHEMBL5134599 | 0.68 | MKNK1 (0.40) | — | |
| SCHEMBL4897814 | 0.67 | PDE5A (0.48) | PDE5A | |
| SCHEMBL3122462 | 0.66 | PDE5A (0.36) | PDE5A | |
| SCHEMBL1253366 | 0.66 | CHRNA7 (0.50) | TRPV1CHRNA7 | |
| SCHEMBL10111229 | 0.64 | PRKCI (0.49) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | claimed |
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | disclosed |