Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134598 | 0.75 | TRPV1 (0.39) | PIK3CB | |
| SCHEMBL4900037 | 0.74 | PDE5A (0.48) | — | |
| SCHEMBL5134607 | 0.68 | LMNA (0.36) | — | |
| SCHEMBL5133891 | 0.67 | NMT1 (0.42) | PRKCI | |
| SCHEMBL4897820 | 0.67 | PDE5A (0.49) | — | |
| SCHEMBL3122462 | 0.66 | PDE5A (0.36) | MAPTMAPK8MAPK9MAPK10 | |
| SCHEMBL18710635 | 0.64 | PRKCI (0.55) | PIK3CBPRKCIFAAHSLC6A2SLC6A4 | |
| SCHEMBL31036076 | 0.62 | CYP2A6 (0.41) | PRKCIFAAHSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13741948 | 0.62 | PRKCI (0.53) | PIK3CBPRKCIFAAHSLC6A2SLC6A4 | |
| SCHEMBL18876154 | 0.61 | PRKCI (0.52) | PIK3CBPRKCIFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | claimed |
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | disclosed |