Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | ICMT | O60725 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133891 | 0.81 | NMT1 (0.42) | HDAC1NMT1PDE5AHDAC6 | |
| SCHEMBL4901866 | 0.75 | PDE5A (0.51) | ALDH1A1HDAC1PDE5AHDAC6 | |
| SCHEMBL5134315 | 0.68 | PDE5A (0.35) | LMNASMN1; SMN2ALDH1A1PDE5A | |
| SCHEMBL4137516 | 0.66 | LMNA (0.31) | LMNA | |
| SCHEMBL4893654 | 0.66 | PDE5A (0.52) | ALDH1A1HDAC1PDE5AHDAC6 | |
| SCHEMBL3122462 | 0.66 | PDE5A (0.36) | LMNASMN1; SMN2ALDH1A1PDE5A | |
| SCHEMBL4904011 | 0.65 | PDE5A (0.52) | ALDH1A1HDAC1NMT1PDE5AHDAC6 | |
| SCHEMBL13988124 | 0.64 | ATM (0.46) | SMN1; SMN2HDAC1 | |
| SCHEMBL5134598 | 0.62 | TRPV1 (0.39) | PDE5A | |
| SCHEMBL4903930 | 0.60 | PDE5A (0.52) | ALDH1A1HDAC1PDE5AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | claimed |
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | disclosed |