Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.33 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134147 | 0.80 | RORC (0.34) | RORCAGXTALKBH1LCKKDR | |
| SCHEMBL4901484 | 0.79 | PDE5A (0.42) | HDAC1HTR1A | |
| SCHEMBL5134311 | 0.74 | GBA1 (0.32) | — | |
| SCHEMBL4905752 | 0.73 | PDE5A (0.41) | HDAC1HTR1A | |
| SCHEMBL4901853 | 0.72 | PDE5A (0.40) | HDAC1HTR1A | |
| SCHEMBL4895854 | 0.71 | PDE5A (0.45) | HDAC1HTR1A | |
| SCHEMBL4142910 | 0.70 | HSP90AA1 (0.37) | AGXTHTR1AHTR1DHTR1B | |
| SCHEMBL4892978 | 0.69 | PDE5A (0.45) | HDAC1HTR1A | |
| SCHEMBL4901618 | 0.68 | PDE5A (0.41) | HDAC1HTR1A | |
| SCHEMBL4128912 | 0.68 | PDE5A (0.41) | HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | claimed |
| WO-2008071650-A2 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-06-19 | — | — | WO | disclosed |