Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betaine SCHEMBL14857276 | 0.99 | APEX1 (0.37) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5170046 | 0.96 | APEX1 (0.37) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5171000 | 0.95 | TSHR (0.39) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5171576 | 0.94 | TSHR (0.41) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5166598 | 0.93 | TSHR (0.43) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5167813 | 0.93 | TSHR (0.43) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5168052 | 0.93 | TSHR (0.43) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5168602 | 0.93 | TSHR (0.43) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5168150 | 0.92 | APEX1 (0.40) | APEX1ALDH1A1LMNATSHRTHRB | |
| Betaine SCHEMBL5171074 | 0.91 | TSHR (0.38) | APEX1ALDH1A1LMNATSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544812-B1 | IMPROVED MICROCAPSULES AND PRODUCTION THEREOF | FOLLMANN GMBH & CO KG (DE) | 2018-10-24 | — | — | EP | claimed |
| EP-1902077-B2 | NEUTRALISED CATIONIC POLYMER, COMPOSITION CONTAINING SAID POLYMER AND A COSMETIC TREATMENT METHOD | OREAL (FR) | 2018-07-18 | — | — | EP | claimed |
| US-10004923-B2 | Neutralised cationic polymer, composition containing said polymer and a cosmetic treatment method | L'OREAL (FR) | 2018-06-26 | — | — | US | claimed |
| US-20160177002-A1 | HYDROGEL FIBERS AND PREPARATION THEREOF | INTELLISIV LTD. (IL) | 2016-06-23 | — | — | US | claimed |
| EP-3027233-A1 | HYDROGEL FIBERS AND PREPARATION THEREOF | Intellisiv Ltd (IL) | 2016-06-08 | — | — | EP | claimed |
| US-9359461-B2 | Ethylene copolymers, compositions comprising same and preparation and treatment methods | L'OREAL (FR) | 2016-06-07 | — | — | US | claimed |
| EP-2705062-B1 | SHEAR STABLE POLYMERS, THEIR PREPARATION AND THEIR USE AS THICKENER | RHODIA OPERATIONS (FR) | 2016-03-23 | — | — | EP | claimed |
| WO-2015015500-A1 | HYDROGEL FIBERS AND PREPARATION THEREOF | INTELLISIV LTD. (IL) | 2015-02-05 | — | — | WO | claimed |
| EP-1765893-B1 | NOVEL ETHYLENE COPOLYMERS, COMPOSITIONS COMPRISING SAME AND PREPARATION AND TREATMENT METHODS | OREAL (FR) | 2012-08-22 | — | — | EP | claimed |
| EP-2124869-B1 | POLYMER PARTICLE DISPERSION, COMPOSITION CONTAINING THE SAME AND COSMETIC TREATMENT METHOD | OREAL (FR) | 2012-08-15 | — | — | EP | claimed |
| EP-1732964-A2 | SEQUENCED COPOLYMER | Arkema France (FR) | 2006-12-20 | — | — | EP | claimed |
| WO-2006013269-A2 | NOVEL ETHYLENE COPOLYMERS, COMPOSITIONS COMPRISING SAME AND PREPARATION AND TREATMENT METHODS | L'OREAL (FR) | 2006-02-09 | — | — | WO | claimed |
| WO-2006013270-A2 | COSMETIC COMPOSITIONS CONTAINING AT LEAST ONE SURFACTANT AND AT LEAST ONE ETHYLENE COPOLYMER WITH POLYETHYLENE GLYCOL GRAFTS | L'ORÉAL (FR) | 2006-02-09 | — | — | WO | claimed |
| US-20060003654-A1 | Dispersible alcohol/cleaning wipes via topical or wet-end application of acrylamide or vinylamide/amine polymers | KIMBERLY-CLARK WORLDWIDE, INC. | 2006-01-05 | — | — | US | claimed |
| EP-1439962-B1 | INK JET RECORDING MEDIUM | CIBA SC HOLDING AG (CH) | 2005-11-16 | — | — | EP | claimed |
| WO-2005103102-A2 | SEQUENCED COPOLYMER | ARKEMA FRANCE (FR) | 2005-11-03 | — | — | WO | claimed |
| US-6533415-B2 | Ocular lens material having hydrophilic surface and process for preparing the same | MENICON CO., LTD. (JP) | 2003-03-18 | — | — | US | claimed |
| US-20010050749-A1 | Ocular lens material having hydrophilic surface and process for preparing the same | MENICON CO., LTD. (JP) | 2001-12-13 | — | — | US | claimed |
| EP-1136521-A2 | Ocular lens material having hydrophilic surface and process for preparing the same | Menicon Co., Ltd. (JP) | 2001-09-26 | — | — | EP | claimed |
| EP-0611781-B1 | Ophthalmic lens polymer incorporating acyclic monomer | JOHNSON & JOHNSON VISION PROD (US) | 1998-06-10 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10004923-B2 | Neutralised cationic polymer, composition containing said polymer and a cosmetic treatment method | KRT18, EYA3, EYA2 | APEX1 1342/4885ALDH1A1 3858/4885LMNA 2637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.