Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPM1D | O15297 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137352 | 0.92 | TLR7 (0.42) | C5AR1AVPR1BTLR7 | |
| SCHEMBL5137681 | 0.91 | PTGES (0.44) | C5AR1HDAC1PTGESLTA4H | |
| SCHEMBL5137864 | 0.89 | C5AR1 (0.44) | C5AR1HDAC1 | |
| SCHEMBL5136637 | 0.88 | C5AR1 (0.45) | C5AR1NPC1SMN1; SMN2MEP1BLTA4H | |
| SCHEMBL5135268 | 0.87 | C5AR1 (0.42) | C5AR1AVPR1BHDAC1 | |
| SCHEMBL5137356 | 0.86 | MEN1 (0.45) | C5AR1SMN1; SMN2WDR5TLR7 | |
| SCHEMBL650435 | 0.86 | C5AR1 (0.42) | C5AR1 | |
| SCHEMBL5135054 | 0.85 | C5AR1 (0.40) | C5AR1HDAC1PTGES | |
| SCHEMBL648532 | 0.85 | C5AR1 (0.41) | C5AR1AVPR1BTLR7 | |
| SCHEMBL5135713 | 0.85 | C5AR1 (0.44) | C5AR1HDAC1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |