Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648304 | 0.93 | C5AR1 (0.41) | MEN1KMT2AC5AR1ADORA2BADORA1 | |
| SCHEMBL648532 | 0.93 | C5AR1 (0.41) | MEN1KMT2AC5AR1TLR7PDE4B | |
| SCHEMBL5137905 | 0.92 | IGF1R (0.43) | MEN1KMT2AC5AR1ALDH1A1 | |
| SCHEMBL5137557 | 0.91 | C5AR1 (0.42) | MEN1KMT2AC5AR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL648763 | 0.91 | C5AR1 (0.40) | MEN1KMT2AC5AR1PDE4BALDH1A1 | |
| SCHEMBL5135374 | 0.91 | C5AR1 (0.40) | MEN1KMT2AC5AR1 | |
| SCHEMBL5137864 | 0.90 | C5AR1 (0.44) | C5AR1ADORA2BADORA1ADORA2APDE4B | |
| SCHEMBL648140 | 0.89 | C5AR1 (0.44) | MEN1KMT2AC5AR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL650496 | 0.89 | C5AR1 (0.40) | MEN1KMT2AC5AR1 | |
| SCHEMBL5135433 | 0.88 | C5AR1 (0.46) | MEN1KMT2AC5AR1TLR7F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |