Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11973436 | 0.75 | P4HB (0.50) | SMN1; SMN2LMNARCE1P4HBTP53 | |
| SCHEMBL15472197 | 0.75 | CCR1 (0.43) | SMN1; SMN2LMNATP53HIF1ACYP2D6 | |
| SCHEMBL29874834 | 0.75 | CCR1 (0.43) | SMN1; SMN2LMNATP53HIF1ACYP2D6 | |
| SCHEMBL28933357 | 0.70 | LMNA (0.52) | SMN1; SMN2LMNARCE1P4HBTP53 | |
| SCHEMBL11973012 | 0.69 | HSP90AA1 (0.52) | SMN1; SMN2LMNARCE1P4HBTP53 | |
| SCHEMBL29875371 | 0.69 | CCR1 (0.37) | SMN1; SMN2LMNATP53HIF1ACYP2D6 | |
| SCHEMBL22552552 | 0.69 | CCR1 (0.37) | SMN1; SMN2LMNATP53HIF1ACYP2D6 | |
| SCHEMBL14033102 | 0.69 | HSP90AA1 (0.47) | SMN1; SMN2LMNAGAAP4HBTP53 | |
| SCHEMBL27317244 | 0.69 | CCR1 (0.37) | SMN1; SMN2LMNATP53HIF1ACYP2D6 | |
| SCHEMBL27317555 | 0.69 | CCR1 (0.37) | SMN1; SMN2LMNATP53HIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898903-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006135627-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-12-21 | — | — | WO | claimed |