Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749666 | 0.88 | GRM5 (0.33) | QPCTGRM5DPP4HPGDTSHR | |
| SCHEMBL2334323 | 0.80 | LMNA (0.38) | GRM5DPP4HPGDTSHR | |
| SCHEMBL30361116 | 0.80 | LMNA (0.38) | GRM5DPP4HPGDTSHR | |
| SCHEMBL2334972 | 0.78 | HPGD (0.39) | GRM5DPP4HPGDTSHRPDE4A | |
| SCHEMBL5061246 | 0.77 | CHRM5 (0.36) | GRM5HCAR2 | |
| SCHEMBL29868304 | 0.77 | QPCT (0.42) | QPCTGRM5DPP4HPGDTSHR | |
| SCHEMBL15385182 | 0.77 | QPCT (0.42) | QPCTGRM5DPP4HPGDTSHR | |
| SCHEMBL2331907 | 0.76 | GRM5 (0.35) | GRM5DPP4HCAR2 | |
| SCHEMBL1667787 | 0.76 | MAPT (0.34) | QPCTGRM5DPP4HPGDTSHR | |
| SCHEMBL2332686 | 0.76 | QPCT (0.35) | QPCTGRM5DPP4HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891042-A2 | 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR THERAPEUTIC USE ON THE CENTRAL NERVOUS SYSTEM | UCB Pharma, S.A. (BE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006128693-A2 | 2 -OXO-I -PYRROLIDINE DERIVATIVES/ PROCESSES FOR PREPARING THEM AND THEIR THERAPEUTIC USE ON THE CENTRAL NERVOUS SYSTEM | UCB PHARMA, S.A. (BE) | 2006-12-07 | — | — | WO | claimed |