Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 6/20 | 0.32 |
| ▸ | THRB | P10828 | 6/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137672 | 0.90 | RAF1 (0.37) | ACSS2RAF1BRAFTHRATHRB | |
| SCHEMBL3142133 | 0.88 | POLB (0.45) | ACSS2POLBRAF1BRAFKDM4E | |
| SCHEMBL3131649 | 0.85 | POLB (0.48) | ACSS2POLBRAF1BRAFKDM4E | |
| SCHEMBL3136098 | 0.77 | ACSS2 (0.35) | ACSS2THRATHRB | |
| SCHEMBL3128023 | 0.77 | ACSS2 (0.35) | ACSS2THRATHRB | |
| SCHEMBL3130577 | 0.75 | ACSS2 (0.40) | ACSS2THRATHRB | |
| SCHEMBL3140982 | 0.74 | ACSS2 (0.37) | ACSS2RAF1BRAFTHRATHRB | |
| SCHEMBL3137120 | 0.73 | POLB (0.46) | ACSS2POLBRAF1BRAFKDM4E | |
| SCHEMBL3131790 | 0.73 | THRA (0.48) | ACSS2POLBKDM4ERIPK1THRA | |
| SCHEMBL3142258 | 0.73 | THRA (0.36) | ACSS2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |