Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820131 | 0.87 | KDM4E (0.33) | LMNACYP3A4KDM4ETDP1MAPT | |
| SCHEMBL1451590 | 0.83 | LMNA (0.47) | LMNACYP3A4KDM4EACHEPOLB | |
| SCHEMBL3820731 | 0.81 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL28084471 | 0.78 | LMNA (0.46) | LMNACYP3A4KDM4EACHEPOLB | |
| SCHEMBL4777768 | 0.77 | ALDH1A1 (0.39) | LMNAKDM4EPOLBGLAGAA | |
| SCHEMBL7083421 | 0.76 | LMNA (0.44) | LMNACYP3A4KDM4EACHEPOLB | |
| SCHEMBL21681471 | 0.76 | CYP4F2 (0.50) | LMNACYP3A4KDM4EACHECYP4F2 | |
| SCHEMBL919169 | 0.75 | — | — | |
| SCHEMBL4242 | 0.74 | — | — | |
| SCHEMBL10605638 | 0.74 | LMNA (0.42) | LMNACYP3A4KDM4EACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781303-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1781303-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | CombinatoRx, Incorporated (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006004803-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX, INCORPORATED (US) | 2006-01-12 | — | — | WO | disclosed |
| US-4755513-A | Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1988-07-05 | — | — | US | disclosed |