Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HCN1 | O60741 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888650 | 0.75 | KCNH2 (0.58) | P2RX7 | |
| SCHEMBL30848473 | 0.69 | MEN1 (0.64) | MEN1KMT2AP2RX7HPGDHCN4 | |
| SCHEMBL14708773 | 0.68 | KDM4E (0.45) | TP53NPC1ALDH1A1 | |
| SCHEMBL27747787 | 0.64 | HPGD (0.69) | MEN1KMT2AHPGDLMNAMAPT | |
| SCHEMBL30686690 | 0.64 | HPGD (0.78) | MEN1KMT2ADRD3HPGDMAPT | |
| SCHEMBL26936103 | 0.64 | HPGD (0.78) | MEN1KMT2ADRD3HPGDMAPT | |
| SCHEMBL26936102 | 0.63 | HPGD (0.86) | MEN1KMT2ADRD3HPGDMAPT | |
| SCHEMBL2470992 | 0.62 | MEN1 (0.74) | MEN1KMT2AP2RX7ALDH1A1 | |
| SCHEMBL30848670 | 0.62 | MEN1 (0.54) | MEN1KMT2AP2RX7HPGDHCN4 | |
| SCHEMBL8559157 | 0.62 | LMNA (0.53) | MEN1KMT2AP2RX7HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |