Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 7/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136171 | 0.85 | PARP1 (0.45) | NAMPTPARP2PARP1CNR1CNR2 | |
| SCHEMBL20822489 | 0.80 | CYP11B1 (0.42) | PARP1JAK2JAK1 | |
| SCHEMBL3840452 | 0.75 | CXCR5 (0.45) | PARP1 | |
| SCHEMBL5190872 | 0.74 | PARP1 (0.42) | NAMPTPARP2PARP1HTR4OPRM1 | |
| SCHEMBL1872682 | 0.74 | PARP1 (0.75) | PARP2PARP1 | |
| SCHEMBL4359667 | 0.73 | CXCR5 (0.52) | PARP1 | |
| SCHEMBL4141784 | 0.71 | CXCR5 (0.51) | PARP1 | |
| SCHEMBL31074260 | 0.71 | CXCR5 (0.51) | PARP1 | |
| SCHEMBL22542104 | 0.70 | NAMPT (0.51) | NAMPTTLR9TLR8TLR7 | |
| SCHEMBL2052014 | 0.70 | IKBKB (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901746-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007002884-A2 | 4-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |