Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | CHUK | O15111 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052016 | 0.84 | IKBKB (0.56) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL3840452 | 0.78 | CXCR5 (0.45) | LMNAHTR1AKDM4EALDH1A1 | |
| SCHEMBL4359667 | 0.75 | CXCR5 (0.52) | HTR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4141784 | 0.74 | CXCR5 (0.51) | HTR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL31074260 | 0.74 | CXCR5 (0.51) | HTR1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL17786108 | 0.72 | PARP1 (0.44) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL20822489 | 0.72 | CYP11B1 (0.42) | LMNAHTR1ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3809365 | 0.72 | PARP1 (0.51) | IKBKBCHUKAURKA | |
| SCHEMBL10326073 | 0.70 | HSD11B1 (0.46) | BTKMEN1KMT2AALDH1A1 | |
| SCHEMBL5136169 | 0.70 | NAMPT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328576-A1 | USE OF NMDA ACTIVITY ENHANCERS TO TREAT HYPERSOMNIA, REDUCED WAKEFULNESS OR REDUCED VIGILANCE | Merck Sharp & Dohme Limited (GB) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010035026-A1 | USE OF NMDA ACTIVITY ENHANCERS TO TREAT HYPERSOMNIA, REDUCED WAKEFULNESS OR REDUCED VIGILANCE | MERCK SHARP & DOHME LTD (GB) | 2010-04-01 | — | — | WO | disclosed |