Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102791 | 0.89 | TLR7 (0.54) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL3183969 | 0.78 | TLR7 (0.62) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL8723784 | 0.77 | TLR7 (0.62) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL5370008 | 0.76 | TLR7 (0.60) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL4753594 | 0.76 | TLR7 (0.59) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL5358343 | 0.75 | TLR7 (0.59) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL6030934 | 0.75 | TLR7 (0.59) | TLR7ADORA2ALMNAPOLBHRH2 | |
| Imiquimod SCHEMBL9602249 | 0.74 | TLR7 (0.82) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL1893718 | 0.74 | TLR7 (0.58) | TLR7ADORA2ALMNAPOLBHRH2 | |
| SCHEMBL13770893 | 0.74 | TLR7 (0.65) | TLR7ADORA2ALMNAPOLBHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948173-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007056112-A2 | HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-05-18 | — | — | WO | disclosed |