Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 7/20 | 0.89 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.89 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.89 |
| ▸ | ESR1 | P03372 | 9/20 | 0.80 |
| ▸ | ESRRG | P62508 | 6/20 | 0.74 |
| ▸ | PDE1A | P54750 | 6/20 | 0.72 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.72 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.72 |
| ▸ | ESRRB | O95718 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24354598 | 0.96 | ESR1 (0.82) | PSMB1PSMB5PSMB2ESR1ESRRG | |
| SCHEMBL14539097 | 0.96 | ESR1 (0.82) | PSMB1PSMB5PSMB2ESR1ESRRG | |
| SCHEMBL5075243 | 0.91 | ESR1 (0.74) | PSMB1PSMB5PSMB2ESR1ESRRG | |
| SCHEMBL5075011 | 0.91 | ESR1 (0.74) | PSMB1PSMB5PSMB2ESR1ESRRG | |
| SCHEMBL5075819 | 0.91 | ESR1 (0.74) | PSMB1PSMB5PSMB2ESR1ESRRG | |
| SCHEMBL30902018 | 0.89 | PSMB1 (1.00) | PSMB1PSMB5PSMB2ESR1PDE1A | |
| SCHEMBL15648408 | 0.89 | PSMB1 (1.00) | PSMB1PSMB5PSMB2ESR1PDE1A | |
| SCHEMBL29822053 | 0.89 | PSMB1 (1.00) | PSMB1PSMB5PSMB2ESR1PDE1A | |
| SCHEMBL7650153 | 0.89 | PSMB1 (1.00) | PSMB1PSMB5PSMB2ESR1PDE1A | |
| SCHEMBL7650156 | 0.89 | PSMB1 (1.00) | PSMB1PSMB5PSMB2ESR1PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951250-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062151-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |