⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653741 | 0.81 | — | — | |
| SCHEMBL1766359 | 0.81 | — | — | |
| SCHEMBL3197403 | 0.78 | — | — | |
| SCHEMBL8068062 | 0.74 | ADH1B (0.71) | — | |
| SCHEMBL8764004 | 0.72 | ADH1B (0.72) | — | |
| SCHEMBL11322360 | 0.72 | ADH1B (0.72) | — | |
| SCHEMBL514333 | 0.72 | — | — | |
| SCHEMBL11467304 | 0.72 | ADH1B (0.56) | — | |
| SCHEMBL979732 | 0.72 | ADH1B (0.72) | — | |
| SCHEMBL8763225 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220388969-A1 | SUBSTITUTED 3,4-DIHYDROQUINAZOLINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2022-12-08 | — | — | US | claimed |
| EP-4021895-A1 | NOVEL QUINAZOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. Hoffmann-La Roche AG (CH) | 2022-07-06 | — | — | EP | claimed |
| CN-114502538-A | Substituted 3, 4-dihydroquinazolines for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114144401-A | Novel quinazoline compounds for the treatment and prevention of hepatitis b virus diseases | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | claimed |
| WO-2021063856-A1 | SUBSTITUTED 3,4-DIHYDROQUINAZOLINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2021-04-08 | — | — | WO | claimed |
| WO-2021037868-A1 | NOVEL QUINAZOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2021-03-04 | — | — | WO | claimed |
| CN-110540513-A | N-vinyl amide and preparation method thereof | UNIV NANKAI | 2019-12-06 | — | — | CN | claimed |
| EP-1189891-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-03-27 | — | — | EP | claimed |
| US-6362342-B1 | BIOSYNTHESIS; DRUG LIBRARIES | LION BIOSCIENCE AG (DE) | 2002-03-26 | — | — | US | claimed |
| WO-2001000594-A1 | TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-01-04 | — | — | WO | claimed |
| US-4853467-A | Nitrogen containing derivatives of epipodophyllotoxin glucosides | BRISTOL-MYERS COMPANY (US) | 1989-08-01 | — | — | US | claimed |
| EP-0291957-A2 | Nitrogen containing derivatives of epipodophyllotoxin glucosides, a process for preparing them and pharmaceutical compositions | Bristol-Myers Squibb Company (US) | 1988-11-23 | — | — | EP | claimed |
| US-4347372-A | Benzoxazolyl-glyoxylonitrile-2-oxime ether derivatives | CIBA-GEIGY CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| EP-3814419-B1 | POLYOLEFIN FORMULATION WITH POLY (2-ALKYL-2-OXAZOLINE) | DOW GLOBAL TECHNOLOGIES LLC (US) | 2025-05-14 | — | — | EP | disclosed |
| CN-117881759-A | Thermoplastic resin composition, resin sheet, and laminate | 宝理塑料赢创有限公司 | 2024-04-12 | — | — | CN | disclosed |
| US-11939455-B2 | Polyolefin formulation with poly(2-alkyl-2-oxazoline) | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-03-26 | — | — | US | disclosed |
| US-3996208-A | PENICILLINS | CIBA-GEIGY CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |
| US-3989695-A | 7β-Amino-cepham-3-ol-4-carboxylic acid compounds | CIBA-GEIGY CORPORATION (US) | 1976-11-02 | — | — | US | disclosed |
| US-3932465-A | ANTIBIOTIC | CIBA-GEIGY CORPORATION (US) | 1976-01-13 | — | — | US | disclosed |
| US-3931268-A | Methylhydrazinomethyl-substituted benzoic acid amides | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |