Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 12/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135374 | 0.93 | C5AR1 (0.40) | C5AR1CETPCRHR1MEN1KMT2A | |
| SCHEMBL648763 | 0.92 | C5AR1 (0.40) | C5AR1CRHR1MEN1KMT2ACCR4 | |
| SCHEMBL650074 | 0.89 | C5AR1 (0.43) | C5AR1CETPCRHR1 | |
| SCHEMBL5137356 | 0.89 | MEN1 (0.45) | C5AR1MEN1KMT2A | |
| SCHEMBL648532 | 0.88 | C5AR1 (0.41) | C5AR1MEN1KMT2A | |
| SCHEMBL648123 | 0.88 | C5AR1 (0.42) | C5AR1CETPCRHR1 | |
| SCHEMBL5137905 | 0.87 | IGF1R (0.43) | C5AR1MEN1KMT2A | |
| SCHEMBL650435 | 0.87 | C5AR1 (0.42) | C5AR1CRHR1MEN1KMT2ACCR4 | |
| SCHEMBL648926 | 0.86 | C5AR1 (0.41) | C5AR1CETPMEN1KMT2A | |
| SCHEMBL5137864 | 0.85 | C5AR1 (0.44) | C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |