Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.43 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648532 | 0.94 | C5AR1 (0.41) | IGF1RBCHEALOX5C5AR1PPARG | |
| SCHEMBL5134916 | 0.92 | BCHE (0.40) | IGF1RBCHEALOX5C5AR1PPARG | |
| SCHEMBL5137356 | 0.92 | MEN1 (0.45) | C5AR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL5135374 | 0.89 | C5AR1 (0.40) | C5AR1KMT2AMEN1 | |
| SCHEMBL648763 | 0.89 | C5AR1 (0.40) | IGF1RBCHEC5AR1KMT2AMEN1 | |
| SCHEMBL5137864 | 0.88 | C5AR1 (0.44) | BCHEC5AR1ALDH1A1HPGD | |
| SCHEMBL5136024 | 0.88 | C5AR1 (0.41) | IGF1RBCHEC5AR1KMT2AMEN1 | |
| SCHEMBL5136497 | 0.88 | C5AR1 (0.41) | IGF1RC5AR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL650496 | 0.87 | C5AR1 (0.40) | C5AR1KMT2AMEN1 | |
| SCHEMBL648304 | 0.87 | C5AR1 (0.41) | BCHEC5AR1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |