Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RORA | P35398 | 1/20 | 0.44 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893427 | 0.84 | PARP1 (0.47) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL1895931 | 0.83 | ALDH1A1 (0.46) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL12668491 | 0.83 | MAPT (0.47) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL12675462 | 0.81 | MAPT (0.45) | MAPTTP53ALDH1A1KDM4ENR5A1 | |
| SCHEMBL13079587 | 0.81 | ALDH1A1 (0.44) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL1892742 | 0.80 | MAPT (0.45) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL1896463 | 0.79 | MAPT (0.48) | MAPTALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL12675444 | 0.78 | NR5A1 (0.46) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL2621633 | 0.78 | MAPT (0.62) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL15869762 | 0.77 | LMNA (0.51) | MAPTTP53ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937643-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |
| EP-1937643-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007109160-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |