Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11197355 | 1.00 | MAPT (0.69) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL31429843 | 1.00 | MAPT (0.69) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL5137639 | 1.00 | MAPT (0.69) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL27970874 | 0.88 | CRHBP (0.57) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL26934245 | 0.87 | ALDH1A1 (0.55) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL26934246 | 0.87 | ALDH1A1 (0.55) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL11236642 | 0.87 | KMT2A (0.58) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL11236645 | 0.87 | KMT2A (0.58) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL6132129 | 0.86 | ALDH1A1 (0.69) | MAPTALDH1A1CRHBPCRHR2HCAR3 | |
| SCHEMBL10505373 | 0.86 | ALDH1A1 (0.69) | MAPTALDH1A1CRHBPCRHR2HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940805-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2008-07-09 | — | — | EP | disclosed |
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
| WO-2007022638-A1 | BENZODIAZEPINE AND BENZOPIPERAZINE ANALOG INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | MAPT 3195/4885ALDH1A1 728/4885CRHBP 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.