Saccharin

Saccharin

SCHEMBL5137729

NC(=O)O.O=C1NS(=O)(=O)c2ccccc21

nearest known ligand 0.81

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 7/20 0.81
CA9 Q16790 7/20 0.81
CA2 P00918 6/20 0.81
CA1 P00915 3/20 0.81
KDM4E B2RXH2 2/20 0.81
CA7 P43166 2/20 0.81
KMT2A Q03164 2/20 0.81
USP2 O75604 1/20 0.81
LMNA P02545 1/20 0.81
BCHE P06276 1/20 0.81
CA4 P22748 1/20 0.81
CA6 P23280 1/20 0.81
CA5A P35218 1/20 0.81
CA14 Q9ULX7 1/20 0.81
CA5B Q9Y2D0 1/20 0.81
HSD11B1 P28845 1/20 0.53
ALDH1A1 P00352 2/20 0.52
GAA P10253 2/20 0.49
MAPT P10636 2/20 0.49
ALPL P05186 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Saccharin SCHEMBL11355404 0.94 CA12 (0.85) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL28045129 0.94 CA12 (0.92) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL28167143 0.93 CA12 (0.81) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL28334570 0.92 CA12 (0.88) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL11600574 0.91 CA12 (0.79) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL29037506 0.90 CA12 (0.92) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL27905604 0.90 CA12 (0.92) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL28134145 0.90 CA12 (0.92) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL3816 0.90 CA12 (1.00) CA12CA9CA2CA1KDM4E
Saccharin SCHEMBL29191365 0.90 CA12 (1.00) CA12CA9CA2CA1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8299172-B2 treating the polysaccharide with basic aqueous solutions, then acylation, carboxymethylation and oxidation to form polysaccharide carboxylates, and reacting with proteins to produce a complex of a polysaccharide carboxylate electrostatically bonded to the proteins SAGINAW VALLEY STATE UNIVERSITY (US) 2012-10-30 US disclosed
US-20080167436-A1 treating the polysaccharide with basic aqueous solutions, then acylation, carboxymethylation and oxidation to form polysaccharide carboxylates, and reacting with proteins to produce a complex of a polysaccharide carboxylate electrostatically bonded to the proteins SAGINAW VALLEY STATE UNIVERSITY 2008-07-10 US disclosed
WO-2004110714-A2 BIODEGRADABLE PLASTICS SAGINAW VALLEY STATE UNIVERSITY (US) 2004-12-23 WO disclosed
US-20040249065-A1 Biodegradable plastics SAGINAW VALLEY STATE UNIVERSITY 2004-12-09 US disclosed