Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314473 | 0.89 | TGFBR1 (0.36) | TGFBR1MAPK14MTORKDM4EALDH1A1 | |
| SCHEMBL5139926 | 0.85 | TGFBR1 (0.35) | TGFBR1MAPK14MTOR | |
| SCHEMBL5138279 | 0.85 | TGFBR1 (0.33) | TGFBR1MAPK14MTOR | |
| SCHEMBL4343678 | 0.76 | TGFBR1 (0.51) | TGFBR1MAPK14MTORRIPK2KDR | |
| SCHEMBL4339418 | 0.76 | TGFBR1 (0.49) | TGFBR1MAPK14MTORRIPK2KDR | |
| SCHEMBL5203629 | 0.75 | TGFBR1 (0.32) | TGFBR1MAPK14 | |
| SCHEMBL4339282 | 0.75 | TGFBR1 (0.62) | TGFBR1MAPK14MTORRIPK2KDR | |
| SCHEMBL4350435 | 0.74 | TGFBR1 (0.49) | TGFBR1MAPK14MTORRIPK2KDR | |
| SCHEMBL5137949 | 0.73 | TGFBR1 (0.39) | TGFBR1MAPK14MTORKDM4EALDH1A1 | |
| SCHEMBL5138599 | 0.71 | TGFBR1 (0.34) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |