Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138564 | 0.71 | TGFBR1 (0.35) | TGFBR1MAPK14 | |
| SCHEMBL5200702 | 0.65 | TGFBR1 (0.42) | TGFBR1MAPK14 | |
| SCHEMBL4347725 | 0.60 | TGFBR1 (0.61) | TGFBR1MAPK14 | |
| SCHEMBL5314473 | 0.60 | TGFBR1 (0.36) | TGFBR1MAPK14 | |
| SCHEMBL4336673 | 0.60 | TGFBR1 (0.62) | TGFBR1MAPK14 | |
| SCHEMBL23292014 | 0.59 | DNMT1 (0.49) | TGFBR1LRRK2DNMT1MAPK14MAPK1 | |
| SCHEMBL30557195 | 0.59 | DNMT1 (0.49) | TGFBR1LRRK2DNMT1MAPK14MAPK1 | |
| SCHEMBL5138279 | 0.58 | TGFBR1 (0.33) | TGFBR1MAPK14 | |
| SCHEMBL5139926 | 0.58 | TGFBR1 (0.35) | TGFBR1MAPK14 | |
| Hydrochloric Acid SCHEMBL30557306 | 0.58 | DNMT1 (0.48) | TGFBR1LRRK2DNMT1MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | claimed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |