Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | CCKBR | P32239 | 3/20 | 0.52 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919772 | 0.98 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17988732 | 0.79 | CCKBR (0.38) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5354075 | 0.78 | MEN1 (0.51) | CES1ALDH1A1HPGDMAPTOPRK1 | |
| SCHEMBL14075304 | 0.77 | TTR (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12407900 | 0.74 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Iodide SCHEMBL30847673 | 0.70 | GABRA1 (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30175096 | 0.69 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3589100 | 0.69 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3589097 | 0.69 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL877728 | 0.69 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390896-B2 | Cyclic malonamides as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA CORPORATION (US) | 2008-06-24 | — | — | US | disclosed |