Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071598 | 0.93 | GPR119 (0.67) | GPR119CYP2C9MKNK1MKNK2 | |
| SCHEMBL391237 | 0.90 | GPR119 (0.69) | GPR119CYP2C9 | |
| SCHEMBL389516 | 0.82 | GPR119 (0.69) | GPR119CYP2C9 | |
| SCHEMBL27734747 | 0.81 | GPR119 (0.70) | GPR119CYP2C9 | |
| SCHEMBL389232 | 0.80 | GPR119 (0.67) | GPR119CYP2C9 | |
| SCHEMBL388981 | 0.80 | GPR119 (0.66) | GPR119CYP2C9 | |
| SCHEMBL389892 | 0.79 | GPR119 (0.68) | GPR119CYP2C9 | |
| SCHEMBL386300 | 0.79 | GPR119 (0.61) | GPR119CYP2C9 | |
| SCHEMBL1902173 | 0.79 | GPR119 (0.72) | GPR119CYP2C9 | |
| SCHEMBL1082296 | 0.79 | GPR119 (0.67) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470699-B2 | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2008-12-30 | — | — | US | claimed |