Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952355 | 0.88 | DRD2 (0.43) | SLC6A4DRD3DRD2DRD4HTR1A | |
| SCHEMBL5088731 | 0.87 | DRD2 (0.41) | DRD3DRD2DRD4HTR1AHTR2A | |
| SCHEMBL4947889 | 0.85 | DRD2 (0.41) | SLC6A4DRD3DRD2DRD4HTR1A | |
| SCHEMBL4950127 | 0.85 | DRD2 (0.42) | SLC6A4DRD3DRD2DRD4HTR1A | |
| SCHEMBL4948673 | 0.84 | SLC6A4 (0.53) | SLC6A4DRD3DRD2HTR1AOPRK1 | |
| SCHEMBL4950273 | 0.84 | ADRA2A (0.45) | SLC6A4DRD3DRD2DRD4HTR1A | |
| SCHEMBL4947477 | 0.82 | DRD3 (0.47) | SLC6A4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL4949597 | 0.82 | SLC6A4 (0.50) | SLC6A4DRD3DRD2HTR1AOPRK1 | |
| SCHEMBL4949782 | 0.81 | SLC6A4 (0.49) | SLC6A4DRD3DRD2HTR1AOPRK1 | |
| SCHEMBL4952129 | 0.80 | SLC6A2 (0.41) | SLC6A4DRD3DRD2DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008526700-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1761524-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2007-03-14 | — | — | EP | claimed |
| WO-2006072430-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2006-07-13 | — | — | WO | claimed |