Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 9/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072767 | 0.85 | ADORA2A (0.60) | PIP4K2AADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL5138974 | 0.80 | KDM4E (0.53) | PIP4K2AADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL6072331 | 0.69 | BCHE (0.53) | ADORA1ADORA2AALDH1A1KDM4EGLA | |
| SCHEMBL31375839 | 0.69 | LATS1 (0.48) | PIP4K2A | |
| SCHEMBL6072047 | 0.69 | ACP1 (0.45) | PIP4K2AADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL5139694 | 0.69 | PIP4K2A (0.47) | PIP4K2AADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL16014103 | 0.68 | ADORA2A (0.52) | ADORA1ADORA2AALDH1A1KDM4EHPGD | |
| SCHEMBL23362941 | 0.68 | HTT (0.54) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL30168456 | 0.68 | HTT (0.54) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL5948594 | 0.68 | PIP4K2A (0.57) | PIP4K2AADORA1ADORA2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432279-B2 | 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2008-10-07 | — | — | US | disclosed |