Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | USP1 | O94782 | 2/20 | 0.44 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.44 |
| ▸ | C1R | P00736 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6072767 | 0.82 | ADORA2A (0.60) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6072331 | 0.80 | BCHE (0.53) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6072054 | 0.79 | ACP1 (0.45) | ACP1BACE1USP1WDR48C1R | |
| SCHEMBL9791332 | 0.77 | ADORA1 (0.62) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6072030 | 0.75 | ADORA2A (0.46) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL6072087 | 0.74 | ADORA1 (0.65) | KDM4EALDH1A1HSD17B10KMT2AADORA2A | |
| SCHEMBL6344165 | 0.73 | PIK3R1 (0.50) | ACP1BACE1USP1WDR48C1R | |
| SCHEMBL1847857 | 0.72 | TRPA1 (0.43) | BACE1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL6252164 | 0.72 | KDM4E (0.60) | KDM4EALDH1A1CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL23911662 | 0.71 | AR (0.41) | BACE1KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ACP1 465/4885BACE1 4635/4885USP1 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.