Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140162 | 1.00 | JAK2 (0.49) | JAK2JAK1TYK2ROCK2ROCK1 | |
| SCHEMBL5956771 | 0.89 | ROCK2 (0.46) | JAK2JAK1TYK2ROCK2ROCK1 | |
| SCHEMBL5956758 | 0.89 | ROCK2 (0.46) | JAK2JAK1TYK2ROCK2ROCK1 | |
| SCHEMBL4440947 | 0.86 | PAK1 (0.35) | JAK2JAK1TYK2IRAK4GSK3B | |
| SCHEMBL4451544 | 0.86 | PAK1 (0.35) | JAK2JAK1TYK2IRAK4GSK3B | |
| SCHEMBL4445996 | 0.86 | PAK1 (0.35) | JAK2JAK1TYK2IRAK4GSK3B | |
| Hydrochloric Acid SCHEMBL5956684 | 0.85 | PAK1 (0.35) | JAK2JAK1TYK2IRAK4GSK3B | |
| SCHEMBL2855646 | 0.84 | ROCK2 (0.51) | JAK2JAK1TYK2ROCK2ROCK1 | |
| SCHEMBL2855653 | 0.84 | ROCK2 (0.51) | JAK2JAK1TYK2ROCK2ROCK1 | |
| SCHEMBL4442282 | 0.84 | ROCK2 (0.51) | JAK2JAK1TYK2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270570-B1 | AMIDE COMPOUNDS AND USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-05-31 | — | — | EP | claimed |
| WO-2008049000-A2 | COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION | UNITED THERAPEUTICS CORPORATION (US) | 2008-04-24 | — | — | WO | disclosed |