Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | TACR3 | P29371 | 7/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049830 | 0.94 | LMNA (0.67) | LMNATACR3TP53TACR2PDE10A | |
| SCHEMBL5048810 | 0.86 | LMNA (0.71) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL5047970 | 0.85 | LMNA (0.67) | LMNATACR3TP53TACR2NPC1 | |
| SCHEMBL5042633 | 0.85 | LMNA (0.56) | LMNATACR3TP53ALDH1A1TACR2 | |
| SCHEMBL1582464 | 0.83 | TACR3 (0.63) | LMNATACR3TP53ALDH1A1KDM4E | |
| SCHEMBL4667070 | 0.82 | LMNA (0.74) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL4668167 | 0.81 | LMNA (0.74) | LMNATACR3TP53PTGFRTACR2 | |
| SCHEMBL1581143 | 0.81 | TACR3 (0.65) | LMNATACR3PDE10A | |
| SCHEMBL4667071 | 0.79 | LMNA (0.71) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL5045637 | 0.79 | TACR3 (0.62) | LMNATACR3TACR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928835-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | Astra Zeneca AB (SE) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035158-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |