Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | TACR3 | P29371 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140190 | 0.86 | LMNA (0.76) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL5041963 | 0.85 | TACR3 (0.55) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL8245169 | 0.82 | TACR3 (0.56) | LMNATACR3TP53ALDH1A1KDM4E | |
| SCHEMBL4667071 | 0.80 | LMNA (0.71) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL5049830 | 0.80 | LMNA (0.67) | LMNATACR3TP53L3MBTL1NPC1 | |
| SCHEMBL5047970 | 0.80 | LMNA (0.67) | LMNATACR3TP53L3MBTL1NPC1 | |
| SCHEMBL4449047 | 0.79 | LMNA (0.69) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL4963091 | 0.79 | LMNA (0.60) | LMNATACR3TP53L3MBTL1 | |
| SCHEMBL4667070 | 0.78 | LMNA (0.74) | LMNATACR3TP53PTGFRALDH1A1 | |
| SCHEMBL4668167 | 0.78 | LMNA (0.74) | LMNATACR3TP53PTGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928835-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | Astra Zeneca AB (SE) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035158-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |