SCHEMBL5140252

SCHEMBL5140252

CCC[PH](=O)O[C@H]1[C@@H](OC2CCCCC2)O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 10/20 0.43
PTPN2 P17706 4/20 0.43
PTPN11 Q06124 4/20 0.43
SSTR1 P30872 1/20 0.43
SSTR2 P30874 1/20 0.43
SSTR4 P31391 1/20 0.43
SSTR3 P32745 1/20 0.43
SSTR5 P35346 1/20 0.43
GJB2 P29033 2/20 0.42
CDC25B P30305 7/20 0.40
NT5E P21589 1/20 0.40
PTPN6 P29350 3/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
TACR2 P21452 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5140581 0.88 PTPN1 (0.43) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5139349 0.88 PTPN1 (0.42) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5139854 0.86 NT5E (0.45) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL9117871 0.85 SSTR1 (0.53) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL9117860 0.85 SSTR1 (0.53) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5139933 0.82 NT5E (0.43) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL10262410 0.81 PTPN1 (0.49) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5140579 0.79 PTPN1 (0.44) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5140251 0.79 PTPN1 (0.45) PTPN1PTPN2PTPN11SSTR1SSTR2
SCHEMBL5139347 0.78 PTPN1 (0.42) PTPN1PTPN2PTPN11SSTR1SSTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8664372-B2 Process for producing 1,2-trans-glycoside compound GLYTECH, INC. (JP) 2014-03-04 US disclosed
US-20120232256-A1 PROCESS FOR PRODUCING 1,2-TRANS-GLYCOSIDE COMPOUND OTSUKA CHEMICAL CO., LTD. 2012-09-13 US disclosed
US-8212013-B2 Phenyl 3,4,6-tri-O-benzyl-2-O-(1,1,2,2-tetramethyl-dimethylene phosphonoyl)- beta -D-thioglucopyranoside; inhibits formation of o-ester by-product resulting from the conventional glycosilation reaction of pyranose compounds of 1,2-trans form, affording 1,2-transglycoside compounds with high selectivity OTSUKA CHEMICAL CO., LTD. (JP) 2012-07-03 US disclosed
US-20080177049-A1 Process for Producing 1,2-Trans-Glycoside Compound GLYTECH, INC. (JP) 2008-07-24 US disclosed
EP-1849794-A1 PROCESS FOR PRODUCING 1,2-TRANS-GLYCOSIDE COMPOUND Otsuka Chemical Co., Ltd. (JP) 2007-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120232256-A1 PROCESS FOR PRODUCING 1,2-TRANS-GLYCOSIDE COMPOUND ADH1C, ADH1A, CYP2E1 PTPN1 2778/4885PTPN2 3058/4885PTPN11 3157/4885
US-20080177049-A1 Process for Producing 1,2-Trans-Glycoside Compound ADH1C, ADH1A, CYP2E1 PTPN1 2778/4885PTPN2 3058/4885PTPN11 3157/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.