Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636823 | 0.83 | HDAC3 (0.37) | SMN1; SMN2PIK3CDCSNK2A2PIK3CAPIK3CG | |
| SCHEMBL4441519 | 0.81 | EGFR (0.40) | PIK3CDPIK3CACA2 | |
| SCHEMBL4537397 | 0.77 | NCF1 (0.36) | CA2DDB1CRBN | |
| SCHEMBL9828753 | 0.71 | POLB (0.47) | POLBSMN1; SMN2MAPK1ALDH1A1PIK3CD | |
| SCHEMBL28286305 | 0.69 | IDO1 (0.57) | POLBSMN1; SMN2MAPK1ALDH1A1DYRK1A | |
| SCHEMBL29940279 | 0.69 | IDO1 (0.57) | POLBSMN1; SMN2MAPK1ALDH1A1DYRK1A | |
| SCHEMBL22048054 | 0.68 | IDO1 (0.48) | POLBSMN1; SMN2MAPK1ALDH1A1PIK3CD | |
| SCHEMBL17672031 | 0.66 | BACE1 (0.55) | POLBSMN1; SMN2MAPK1ALDH1A1NPC1 | |
| SCHEMBL5584438 | 0.66 | IDO1 (0.52) | POLBSMN1; SMN2MAPK1ALDH1A1NPC1 | |
| SCHEMBL11460811 | 0.65 | BACE1 (0.58) | POLBSMN1; SMN2MAPK1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | POLB 3047/4885SMN1; SMN2 2437/4885MAPK1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.