Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.50 |
| ▸ | KIT | P10721 | 8/20 | 0.50 |
| ▸ | FLT3 | P36888 | 8/20 | 0.50 |
| ▸ | FLT1 | P17948 | 7/20 | 0.50 |
| ▸ | CSF1R | P07333 | 6/20 | 0.50 |
| ▸ | FLT4 | P35916 | 6/20 | 0.50 |
| ▸ | LCK | P06239 | 5/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | TEK | Q02763 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | LYN | P07948 | 4/20 | 0.50 |
| ▸ | BLK | P51451 | 4/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58313 | 0.92 | KDR (0.59) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL5140618 | 0.86 | KDR (0.45) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL66159 | 0.83 | FLT3 (0.56) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL60464 | 0.83 | KDR (0.57) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL58543 | 0.80 | RIPK1 (0.58) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL57890 | 0.80 | KDR (0.53) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL57834 | 0.78 | IKBKE (0.59) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL58732 | 0.78 | FLT3 (0.53) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL59547 | 0.77 | FLT3 (0.55) | KDRKITFLT3FLT1CSF1R | |
| SCHEMBL10272909 | 0.76 | AURKA (0.59) | KDRKITFLT3FLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |