Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.56 |
| ▸ | THRA | P10827 | 9/20 | 0.56 |
| ▸ | THRB | P10828 | 9/20 | 0.56 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | ASPH | Q12797 | 1/20 | 0.56 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403825 | 0.91 | EGLN1 (0.67) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523153 | 0.81 | THRA (0.84) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL12955515 | 0.81 | EGLN1 (0.55) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL4551499 | 0.78 | EGLN1 (0.53) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523036 | 0.77 | EGLN1 (0.84) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL520736 | 0.77 | EGLN1 (0.51) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL14672078 | 0.74 | EGLN1 (0.71) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL27735256 | 0.74 | EGLN1 (0.61) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL4551839 | 0.74 | EGLN1 (0.53) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL5136364 | 0.73 | EGLN2 (0.63) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |