Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175763 | 0.93 | MAOB (0.39) | MAPTLMNAMAOBBCHEACHE | |
| SCHEMBL5012931 | 0.91 | BCHE (0.43) | LMNAMAOBITGB1ITGA4BCHE | |
| SCHEMBL5011233 | 0.90 | KDM4E (0.41) | POLBITGB1ITGA4KMT2A | |
| SCHEMBL16175594 | 0.90 | KDM4E (0.41) | POLBITGB1ITGA4KMT2A | |
| SCHEMBL5058772 | 0.90 | MAOB (0.38) | RAB9AMAPTLMNAMAOBBCHE | |
| SCHEMBL5015745 | 0.90 | MAOB (0.38) | RAB9AMAPTLMNAMAOBBCHE | |
| SCHEMBL5012266 | 0.89 | PANK3 (0.41) | MAPTLMNAMAOBBCHEACHE | |
| SCHEMBL5012280 | 0.89 | KMT2A (0.45) | ITGB1ITGA4KMT2A | |
| SCHEMBL5012899 | 0.89 | KMT2A (0.46) | RAB9AMAPTKMT2A | |
| SCHEMBL5012261 | 0.88 | KMT2A (0.46) | MAPTITGB1ITGA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |