Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012261 | 0.98 | KMT2A (0.46) | KMT2AF2F10PRSS1ITGB1 | |
| SCHEMBL5012913 | 0.96 | KMT2A (0.44) | KMT2AF2F10PRSS1ITGB1 | |
| SCHEMBL5012290 | 0.95 | F10 (0.43) | KMT2AF2F10PRSS1KDM4E | |
| SCHEMBL5012813 | 0.93 | MAPT (0.42) | KMT2AITGB1ITGA4KDM4E | |
| SCHEMBL5012860 | 0.91 | HTT (0.41) | KMT2AF2F10PRSS1KDM4E | |
| SCHEMBL5011233 | 0.90 | KDM4E (0.41) | KMT2AITGB1ITGA4KDM4E | |
| SCHEMBL5012899 | 0.90 | KMT2A (0.46) | KMT2ACACNA1HCACNA1C | |
| SCHEMBL16175594 | 0.90 | KDM4E (0.41) | KMT2AITGB1ITGA4KDM4E | |
| SCHEMBL5012848 | 0.90 | FAAH (0.42) | KMT2AF2F10PRSS1KDM4E | |
| SCHEMBL5061182 | 0.89 | KDM4E (0.43) | KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |