Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012280 | 0.90 | KMT2A (0.45) | KMT2ACACNA1HCACNA1C | |
| SCHEMBL16175594 | 0.90 | KDM4E (0.41) | KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5011233 | 0.90 | KDM4E (0.41) | KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16175669 | 0.90 | MAPT (0.40) | KMT2AMEN1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL5014495 | 0.90 | CACNA1H (0.42) | KMT2AMEN1CACNA1HCACNA1CALDH1A1 | |
| SCHEMBL5012913 | 0.90 | KMT2A (0.44) | KMT2AHTT | |
| SCHEMBL5012261 | 0.90 | KMT2A (0.46) | KMT2ACACNA1HCACNA1CMAPT | |
| SCHEMBL5015689 | 0.90 | KMT2A (0.43) | KMT2AMEN1MAPK10HTTALDH1A1 | |
| SCHEMBL5012816 | 0.90 | FPR1 (0.40) | KMT2A | |
| SCHEMBL5061182 | 0.89 | KDM4E (0.43) | KMT2AMEN1HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |