Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | XBP1 | P17861 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5140916 | 1.00 | LMNA (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965219 | 0.88 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL967167 | 0.88 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL967168 | 0.88 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965220 | 0.85 | GRK2 (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965578 | 0.82 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965577 | 0.82 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965311 | 0.82 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL964028 | 0.80 | LMNA (0.44) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL965312 | 0.79 | GRK2 (0.47) | LMNAMAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-A4 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1678168-A2 | P70S6 KINASE MODULATORS AND METHOD OF USE | Exelixis, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005039506-A2 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2005-05-06 | — | — | WO | disclosed |