Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 11/20 | 0.39 |
| ▸ | CTSS | P25774 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057398 | 0.93 | CA1 (0.44) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL23909463 | 0.80 | CA1 (0.44) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL1370493 | 0.80 | CA1 (0.44) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL23909464 | 0.80 | CA1 (0.44) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL4555890 | 0.77 | CTSK (0.46) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL12188121 | 0.77 | CA1 (0.41) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL6056683 | 0.77 | KMT2A (0.41) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL6014816 | 0.77 | KMT2A (0.41) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL9509419 | 0.77 | CA1 (0.40) | CA1CA2CA7CTSLCTSK | |
| SCHEMBL25663609 | 0.76 | CA1 (0.46) | CA1CA2CA7CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |