Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990377 | 1.00 | PLK1 (0.37) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL2988050 | 0.94 | PLK1 (0.37) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL2988048 | 0.94 | PLK1 (0.37) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL13206472 | 0.93 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL13574894 | 0.86 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL2986971 | 0.85 | PLK1 (0.41) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL3148252 | 0.84 | PLK1 (0.38) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL4778390 | 0.84 | PLK1 (0.38) | PLK1PLK3RAB9ACYP3A4CYP2C9 | |
| SCHEMBL4560751 | 0.84 | PLK1 (0.41) | PLK1PLK3RAB9A | |
| SCHEMBL2986549 | 0.84 | RAB9A (0.36) | PLK1PLK3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937671-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SmithKline Beecham Corporation (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007030361-A2 | BENZIMIDAZOLE THIOPHENE COMPOUNDS AS PLK INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |