Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.43 |
| ▸ | THRA | P10827 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.43 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335037 | 0.84 | EGLN1 (0.44) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL5335045 | 0.84 | EGLN1 (0.44) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522237 | 0.79 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522238 | 0.79 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522661 | 0.79 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522261 | 0.76 | EGLN1 (0.47) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL523239 | 0.75 | EGLN1 (0.50) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL523180 | 0.75 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522923 | 0.75 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 | |
| SCHEMBL522922 | 0.75 | FTO (0.72) | EGLN1THRATHRBFTOBBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | claimed |