Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.73 |
| ▸ | TSHR | P16473 | 9/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.32 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL17685705 | 1.00 | ALDH1A1 (0.73) | ALDH1A1TSHRFGFR4LMNATP53 | |
| Acrylamide SCHEMBL6005592 | 1.00 | — | — | |
| Acrylamide SCHEMBL9394608 | 0.97 | ALDH1A1 (0.69) | ALDH1A1TSHRFGFR4LMNATP53 | |
| Acrylamide SCHEMBL7752342 | 0.89 | — | — | |
| Acrylamide SCHEMBL28271793 | 0.89 | TSHR (0.58) | ALDH1A1TSHRFGFR4LMNATP53 | |
| Acrylamide SCHEMBL28277051 | 0.88 | — | — | |
| Succinic Acid SCHEMBL29045660 | 0.87 | TSHR (0.55) | ALDH1A1TSHRFGFR4LMNAMAPK1 | |
| Acrylamide SCHEMBL170034 | 0.86 | TSHR (1.00) | ALDH1A1TSHRFGFR4LMNATP53 | |
| Acrylamide SCHEMBL1332245 | 0.86 | — | — | |
| Acrylamide SCHEMBL183292 | 0.86 | TSHR (1.00) | ALDH1A1TSHRFGFR4LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11364695-B2 | Silicone hydrogel lenses with water-rich surfaces | ALCON INC. (CH) | 2022-06-21 | — | — | US | claimed |
| CN-114133479-A | Preparation method of high-molecular polymer for thermal transfer printing ink | 张家港凯宝来环保科技有限公司 | 2022-03-04 | — | — | CN | claimed |
| EP-3268804-B1 | MESH SIZE CONTROL OF LUBRICATION IN GEMINI HYDROGELS | UNIV FLORIDA (US) | 2020-11-04 | — | — | EP | claimed |
| US-20200339836-A1 | SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES | ALCON INC. (CH) | 2020-10-29 | — | — | US | claimed |
| US-10781340-B2 | Silicone hydrogel lenses with water-rich surfaces | ALCON INC. (CH) | 2020-09-22 | — | — | US | claimed |
| US-10723842-B2 | Mesh size control of lubrication in gemini hydrogels | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-07-28 | — | — | US | claimed |
| CN-110746555-A | Preparation method of bionic bait material | 界首市兴华渔具有限公司 | 2020-02-04 | — | — | CN | claimed |
| US-10513628-B2 | Silicone hydrogel lenses with water-rich surfaces | NOVARTIS AG (CH) | 2019-12-24 | — | — | US | claimed |
| US-20190055427-A1 | SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES | ALCON INC. (CH) | 2019-02-21 | — | — | US | claimed |
| US-10131815-B2 | Silicone hydrogel lenses with water-rich surfaces | NOVARTIS AG (CH) | 2018-11-20 | — | — | US | claimed |
| EP-2513711-B1 | METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS | NOVARTIS AG (CH) | 2017-07-12 | — | — | EP | claimed |
| WO-2016145204-A1 | MESH SIZE CONTROL OF LUBRICATION IN GEMINI HYDROGELS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-09-15 | — | — | WO | claimed |
| US-9005492-B2 | Methods for making silicone hydrogel lenses from water-based lens formulations | NOVARTIS AG (CH) | 2015-04-14 | — | — | US | claimed |
| US-8883051-B2 | Methods for increasing the ion permeability of contact lenses | NOVARTIS AG (CH) | 2014-11-11 | — | — | US | claimed |
| EP-2513711-A1 | METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS | Novartis AG (CH) | 2012-10-24 | — | — | EP | claimed |
| EP-2510051-A1 | METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES | Novartis AG (CH) | 2012-10-17 | — | — | EP | claimed |
| WO-2011075377-A1 | METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011071790-A1 | METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES | NOVARTIS AG (CH) | 2011-06-16 | — | — | WO | claimed |
| US-20110140292-A1 | METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS | ALCON INC. (CH) | 2011-06-16 | — | — | US | claimed |
| US-20110133350-A1 | METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES | ALCON INC. (CH) | 2011-06-09 | — | — | US | claimed |