Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985509 | 0.79 | KMT2A (0.56) | KMT2AUSP2GAATSHRMAPK1 | |
| SCHEMBL4985506 | 0.79 | KMT2A (0.50) | KMT2AUSP2GAATSHRMAPK1 | |
| SCHEMBL5141447 | 0.73 | L3MBTL1 (0.40) | KMT2AUSP2TSHRMAPK1ALDH1A1 | |
| SCHEMBL5142759 | 0.73 | MEN1 (0.43) | KMT2ATSHRMAPK1ALDH1A1PKM | |
| SCHEMBL5142770 | 0.72 | ALDH1A1 (0.48) | KMT2ATSHRALDH1A1PKMRAB9A | |
| SCHEMBL5141465 | 0.72 | EPHX2 (0.40) | KMT2AGAAALDH1A1PKMMEN1 | |
| SCHEMBL14272442 | 0.70 | TSHR (0.48) | KMT2AUSP2GAATSHRMAPK1 | |
| SCHEMBL13532412 | 0.70 | KMT2A (0.44) | KMT2AUSP2GAATSHRMAPK1 | |
| SCHEMBL4982944 | 0.69 | KMT2A (0.53) | KMT2AUSP2GAATSHRALDH1A1 | |
| SCHEMBL4982938 | 0.69 | KMT2A (0.48) | KMT2AUSP2TSHRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |